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Image Search Results
Journal: ACS Chemical Biology
Article Title: Structural Characterization of the Reaction and Substrate Specificity Mechanisms of Pathogenic Fungal Acetyl-CoA Synthetases
doi: 10.1021/acschembio.1c00484
Figure Lengend Snippet: Overview of fungal orthologs of Acs1 bound to propyl-AMP. Structures shown such that the N-terminal domain (NTD) is light shades, while the C-terminal domain (CTD) and the N-terminal extension (NT-Ext) are in darker shades and the compounds are in spheres. Aspergillus fumigatus (green, PDB 7KDN, 2.8 Å), Candida albicans (blue, PDB 7KDS, 2.9 Å), Coccidioides immitis (pink, PDB 7KQ6, 1.8 Å), Coccidioides posadasii (yellow, PDB 7KCP, 2.15 Å), and Cryptococcus neoformans in two conformations—thioesterification (orange), adenylation (red, PDB 5IFI, 1.95 Å).
Article Snippet: Full length ACS1 genes for
Techniques:
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Journal: ACS Chemical Biology
Article Title: Structural Characterization of the Reaction and Substrate Specificity Mechanisms of Pathogenic Fungal Acetyl-CoA Synthetases
doi: 10.1021/acschembio.1c00484
Figure Lengend Snippet: Biochemical Properties of Recombinant Fungal Acs1
Article Snippet: Full length ACS1 genes for
Techniques: Recombinant, Activity Assay
Journal: Journal of Clinical Microbiology
Article Title: Are In Vitro Susceptibilities to Azole Antifungals Predictive of Clinical Outcome in the Treatment of Candidemia?
doi: 10.1128/JCM.01072-18
Figure Lengend Snippet: Clinical breakpoints and epidemiologic cutoff values for Candida species and azole antifungals a , b
Article Snippet: In 2012, the
Techniques: